Trial Size CASP3 Antibodies Available Through The Antibody Validation Project

Trial Size CASP3 Antibodies Available Through The Antibody Validation Project

Trial Size CASP3 Antibodies Available Through The Antibody Validation Project

Abstract:

What is CASP3?

Caspase-3, also known as an executioner caspase in apoptosis, receives this name because of its role in the logistics of the destruction of cellular structures such as DNA fragmentation and degradation of cytoskeletal proteins. It is a heterotetramer which is made up of of two anti-parallel arranged heterodimers.

Where is CASP3 found?

Active Caspase-3 is mainly found in the cytosol and is highly expressed in the lungs, spleen, heart, liver and kidneys, and particularly in cells of the immune system. It is also found in lower levels the in brain and skeletal muscle, and rarely in testis.

What role does CASP3 play in disease?

CASP3 is a member of a family of Caspases. It is known that this particular member is involved in the neuronal death in Alzheimer's disease and cleavage of amyloid-beta 4A precursor. It is mainly involved in the activation cascade of caspases who take part in apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly- (ADP-ribose) polymerase (PARP) and splits and activates SREBPs between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. This in turn activates caspase-6, -7 and -9 in downstream processes and takes part in the cleavage of huntingtin.

CASP3 antibodies in the Antibody Validation Project

St John's Laboratory offers a variety of CASP3 trial size primary antibodies, which are available to try through the Antibody Validation Project. Below we highlight those which have already been reviewed, as well as others which are available to try.

Customer reviewed CASP3 antibodies

ModelNameHostClonalityRatingApplication Tested
STJ97448Anti-Active Caspase-3 antibody MouseMonoclonal4WB
STJ90026Anti-Cleaved-Caspase-3 p17 (D175) antibody RabbitPolyclonal5WB
STJ90026Anti-Cleaved-Caspase-3 p17 (D175) antibody RabbitPolyclonal5WB

Other CASP3 antibodies available in the Antibody Validation Project

ModelNameHostClonalityRecommended Applications
STJ150275Mouse CASP3 ELISA Kit  ELISA
STJ150494Rat CASP3 ELISA Kit  ELISA
STJ90003Anti-Cleaved-Caspase-3 p12 (D175) antibodyRabbitPolyclonalWB,IHC,ELISA
STJ90004Anti-Cleaved-Caspase-3 p17 (D175) antibodyRabbitPolyclonalIHC,ELISA
STJ90005Anti-Cleaved-Caspase-3 p17 (D175) antibodyRabbitPolyclonalWB,IHC,ELISA
STJ90025Anti-Caspase-3 antibodyRabbitPolyclonalWB,ELISA
STJ90887Anti-Phospho-Caspase-3 (S150) antibodyRabbitPolyclonalWB,IHC,ELISA
STJ92021Anti-Caspase-3 antibodyRabbitPolyclonalWB,IHC,IF,ELISA
STJ96569Anti-Caspase-3 antibodyRabbitPolyclonalWB,ELISA
STJ97448Anti-Active Caspase-3 antibodyMouseMonoclonalIF,IHC,WB
STJ97452Anti-Caspase-3 antibodyRabbitPolyclonalWB,IHC
STJ97723Anti-Caspase-3 antibodyMouseMonoclonalIHC
STJ97730Anti-Caspase-3 antibodyMouseMonoclonalIHC
STJ98967Anti-Caspase-3 antibodyRabbitPolyclonalWB,ELISA
STJ99611Anti-Caspase 3 antibodyRabbitPolyclonalWB,ELISA
STJ99659Anti-Caspase 3 p17 antibodyRabbitPolyclonalWB,ELISA
ModelNameHostClonalityRecommended Applications
STJ112894Anti-CASP3 AntibodyRabbitMonoclonalWB,IHC,IF
STJ112896Anti-CASP3 AntibodyRabbitMonoclonalWB,IHC,IF,IP
STJ113073Anti-CASP3 AntibodyRabbitPolyclonalIHC
STJ113445Anti-CASP3 AntibodyRabbitMonoclonalWB,IHC,IF,IP,FC
STJ113694Anti-CASP3 AntibodyRabbitPolyclonalWB,IF
STJ113869Anti-CASP3 AntibodyRabbitPolyclonalWB,IHC,IF
STJ22899Anti-CASP3 AntibodyRabbitPolyclonalWB
STJ22900Anti-CASP3 AntibodyRabbitPolyclonalWB
STJ70944Anti-CASP3 AntibodyGoatPolyclonalELISA,WB

How does the Antibody Validation Project work?

In order to help our customers with their choice of antibody with low risk, we offer one of the largest ranges of primary antibodies with trial size options available.

The Antibody Validation Project works like this.
1. Order your trial size antibody online.
2. Explore its suitability.
3. Return your results by posting them on the product page.
4. Receive a sample refund.

Find out more here.

For more related products check out our related categories.

Categories
Antibodies
Antibody Validation Project
Elisa Kits
Extracellular Matrix Organisation
Goat Polyclonals
Immune System
Monoclonal Antibodies
Mouse Monoclonals
Phospho Antibodies
Polyclonal Antibodies
Post Translational Modification Antibodies
Primary Antibody
Programmed Cell Death
Rabbit Monoclonals
Rabbit Polyclonals
Research Area
Sandwich ELISA kits
Signal Transduction