Anti-CAR antibody




 
Description
Rabbit polyclonal against CAR
 


Product Information

Model STJ91996
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, WB
Immunogen Synthesized peptide derived from human CAR
Gene ID 1525
Dilution range WB 1:500-1:2000
ELISA 1:20000
Specificity CAR Polyclonal Antibody detects endogenous levels of CAR protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Note For Research Use Only (RUO).
Protein Name Coxsackievirus and adenovirus receptor
CAR
hCAR
CVB3-binding protein
Coxsackievirus B-adenovirus receptor
HCVADR
Clonality Polyclonal
Conjugation Unconjugated
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration 1 mg/ml
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Database Links HGNC:2559
OMIM:602621
Alternative Names Coxsackievirus and adenovirus receptor
CAR
hCAR
CVB3-binding protein
Coxsackievirus B-adenovirus receptor
HCVADR
Function Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. (Microbial infection) Acts as a receptor for adenovirus type C . Acts as a receptor for Coxsackievirus B1 to B6 .
Sequence and Domain Family The Ig-like C2-type 1 domain mediates homodimerization and interaction with JAML.; The PDZ-binding motif mediates interaction with MPDZ and BAIAP1.
Cellular Localization Isoform 1: Cell membrane Basolateral cell membrane Cell junction, tight junction Cell junction, adherens junction. In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions . In airway epithelial cells localized to basolateral membrane but not to apical surface . Isoform 3: Secreted Isoform 4: Secreted Isoform 5: Secreted
Post-translational Modifications N-glycosylated. Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane.


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