Anti-PARP-3 antibody

Description

Rabbit polyclonal against PARP-3

Product Information

Model	STJ94960

Host	Rabbit

Reactivity	Human

Applications	ELISA, IHC-p

Immunogen	Synthesized peptide derived from human PARP-3

Gene ID	10039

Dilution range	IHC 1:100-1:300 ELISA 1:5000

Specificity	PARP-3 polyclonal antibody detects endogenous levels of PARP-3 protein.

Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Note	FOR RESEARCH USE ONLY (RUO).

Protein Name	Protein Mono-Adp-Ribosyltransferase Parp3 Adp-Ribosyltransferase Diphtheria Toxin-Like 3 Artd3 Dna Adp-Ribosyltransferase Parp3 Irt1 Nad(+ Adp-Ribosyltransferase 3 Adprt-3 Poly [Adp-Ribose] Polymerase 3 Parp-3 Hparp-3 Poly[Adp-Ribose] Synthase 3 Padprt-3

Clonality	Polyclonal

Conjugation	Unconjugated

Isotype	IgG

Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration	1 mg/ml

Storage Instruction	Store at-20°C, and avoid repeat freeze-thaw cycles.

Database Links	HGNC:273 OMIM:607726

Alternative Names	Anti-Protein Mono-Adp-Ribosyltransferase Parp3 antibody Anti-Adp-Ribosyltransferase Diphtheria Toxin-Like 3 antibody Anti-Artd3 antibody Anti-Dna Adp-Ribosyltransferase Parp3 antibody Anti-Irt1 antibody Anti-Nad(+ Adp-Ribosyltransferase 3 antibody Anti-Adprt-3 antibody Anti-Poly [Adp-Ribose] Polymerase 3 antibody Anti-Parp-3 antibody Anti-Hparp-3 antibody Anti-Poly[Adp-Ribose] Synthase 3 antibody Anti-Padprt-3 antibody Anti-PARP3 ADPRT3 ADPRTL3 antibody

Alternative Names

Anti-Protein Mono-Adp-Ribosyltransferase Parp3 antibody
Anti-Adp-Ribosyltransferase Diphtheria Toxin-Like 3 antibody
Anti-Artd3 antibody
Anti-Dna Adp-Ribosyltransferase Parp3 antibody
Anti-Irt1 antibody
Anti-Nad(+ Adp-Ribosyltransferase 3 antibody
Anti-Adprt-3 antibody
Anti-Poly [Adp-Ribose] Polymerase 3 antibody
Anti-Parp-3 antibody
Anti-Hparp-3 antibody
Anti-Poly[Adp-Ribose] Synthase 3 antibody
Anti-Padprt-3 antibody
Anti-PARP3 ADPRT3 ADPRTL3 antibody

Function	Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage. Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks. Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ). Cooperates with the XRRC6-XRCC5 (Ku70-Ku80) heterodimer to limit end-resection thereby promoting accurate NHEJ. Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as XRRC5 and XRCC6. ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'-or 3'-terminal phosphate residues in DNA containing multiple strand breaks. Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA/AID on the chromatin.

Function

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage. Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks. Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ). Cooperates with the XRRC6-XRCC5 (Ku70-Ku80) heterodimer to limit end-resection thereby promoting accurate NHEJ. Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as XRRC5 and XRCC6. ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'-or 3'-terminal phosphate residues in DNA containing multiple strand breaks. Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA/AID on the chromatin.

Cellular Localization	Nucleus Chromosome Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Centriole Almost Exclusively Localized In The Nucleus And Appears In Numerous Small Foci And A Small Number Of Larger Foci Whereas A Centrosomal Location Has Not Been Detected In Response To Dna Damage Localizes To Sites Of Double-Strand Break Preferentially Localized To The Daughter Centriole

Post-translational Modifications	Auto-mono-ADP-ribosylated.

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