Anti-SUMO-1 antibody

Rabbit polyclonal to SUMO-1.

Product Information

Model STJ95835
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, IF, IHC, WB
Immunogen Synthesized peptide derived from human SUMO-1
Gene ID 7341
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Specificity SUMO-1 Polyclonal Antibody detects endogenous levels of SUMO-1 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Note For Research Use Only (RUO).
Protein Name Small ubiquitin-related modifier 1
GAP-modifying protein 1
SMT3 homolog 3
Ubiquitin-homology domain protein PIC1
Ubiquitin-like protein SMT3C
Ubiquitin-like protein UBL1
Clonality Polyclonal
Conjugation Unconjugated
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration 1 mg/ml
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Database Links HGNC:12502
Alternative Names SUMO-1
Small ubiquitin-related modifier 1 antibody
SUMO-1 antibody
GAP-modifying protein 1 antibody
GMP1 antibody
SMT3 homolog 3 antibody
Sentrin antibody
Ubiquitin-homology domain protein PIC1 antibody
Ubiquitin-like protein SMT3C antibody
Smt3C antibody
Ubiquitin-like protein UBL1 antibody
SMT3C antibody
SMT3H3 antibody
UBL1 antibody
OK/SW-cl.43 antibody
Function Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 . Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 .
Cellular Localization Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus, PML body. Cell membrane Nucleus. Recruited by BCL11A into the nuclear body. In the presence of ZFHX3, sequesterd to nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body.
Post-translational Modifications Cleavage of precursor form by SENP1 or SENP2 is necessary for function.; Polymeric SUMO1 chains undergo polyubiquitination by RNF4.

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