Anti-ABCG2 antibody




 
Description
Rabbit polyclonal against ABCG2
 


Product Information

Model STJ97253
Host Rabbit
Reactivity Human
Applications ELISA, IF, IHC-p, WB
Immunogen Synthesized peptide derived from human ABCG2.
Gene ID 9429
Dilution range IF 1:50-200
WB 1:500-1:2000
IHC-p 1:100-1:300
ELISA 1:10000
Specificity ABCG2 polyclonal antibody detects endogenous levels of ABCG2 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Note FOR RESEARCH USE ONLY (RUO).
Protein Name Broad Substrate Specificity Atp-Binding Cassette Transporter Abcg2
Atp-Binding Cassette Sub-Family G Member 2
Breast Cancer Resistance Protein
Cdw338
Mitoxantrone Resistance-Associated Protein
Placenta-Specific Atp-Binding Cassette Transporter
Urate Exporter
Cd Antigen Cd338
Clonality Polyclonal
Conjugation Unconjugated
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration 1 mg/ml
Storage Instruction Store at-20°C, and avoid repeat freeze-thaw cycles.
Database Links HGNC:74
OMIM:138900
Alternative Names Anti-Broad Substrate Specificity Atp-Binding Cassette Transporter Abcg2 antibody
Anti-Atp-Binding Cassette Sub-Family G Member 2 antibody
Anti-Breast Cancer Resistance Protein antibody
Anti-Cdw338 antibody
Anti-Mitoxantrone Resistance-Associated Protein antibody
Anti-Placenta-Specific Atp-Binding Cassette Transporter antibody
Anti-Urate Exporter antibody
Anti-Cd Antigen Cd338 antibody
Anti-ABCG2 ABCP BCRP BCRP1 MXR antibody
Function Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion. In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate. Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates. Mediates the secretion of the riboflavin and biotin vitamins into milk. Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability. Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux. In placenta, it limits the penetration of drugs from the maternal plasma into the fetus. May play a role in early stem cell self-renewal by blocking differentiation.
Cellular Localization Cell Membrane
Multi-Pass Membrane Protein
Apical Cell Membrane
Mitochondrion Membrane
Enriched In Membrane Lipid Rafts
Post-translational Modifications N-glycosylated. Glycosylation-deficient ABCG2 is normally expressed and functional.; Phosphorylated. Phosphorylation at Thr-362 by PIM1 is induced by drugs like mitoxantrone and is associated with cells increased drug resistance. It regulates the localization to the plasma membrane, the homooligomerization and therefore, the activity of the transporter.


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