Anti-ROBO1 antibody




 
Description
Rabbit polyclonal against ROBO1
 


Product Information

Model STJ191349
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, WB
Immunogen Synthesized peptide derived from human ROBO1 protein.
Gene ID 6091
Dilution range WB 1:500-2000
ELISA 1:5000-20000
Specificity ROBO1 polyclonal antibody detects endogenous levels of protein.
Purification ROBO1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Note FOR RESEARCH USE ONLY (RUO).
Protein Name Roundabout homolog 1
Deleted in U twenty twenty
H-Robo-1
Clonality Polyclonal
Conjugation Unconjugated
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Concentration 1 mg/ml
Storage Instruction Store at-20°C, and avoid repeat freeze-thaw cycles.
Database Links HGNC:10249
OMIM:602430
Alternative Names Roundabout homolog 1
Deleted in U twenty twenty
H-Robo-1
Function Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA. May be required for lung development.
Cellular Localization Cell membrane Cell projection, axon. Detected at growth cones in thalamus neurons.
Post-translational Modifications Ubiquitinated. May be deubiquitinated by USP33.


St John's Laboratory Ltd http://www.stjohnslabs.com/ +44 (0)207 681 2580
  [email protected] +44 (0)208 223 3081