Anti-DCSTAMP antibody

Rabbit polyclonal against DCSTAMP

Product Information

Model STJ116837
Host Rabbit
Reactivity Human
Applications WB
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 401-470 of human DCSTAMP (NP_110415. 1).
Gene ID 81501
Dilution range WB 1:500-1:2000
Purification Affinity purification
Protein Name Dendritic Cell-Specific Transmembrane Protein
Dendrocyte-Expressed Seven Transmembrane Protein
Il-Four-Induced Protein
Transmembrane 7 Superfamily Member 4
Clonality Polyclonal
Conjugation Unconjugated
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Instruction Store at-20°C and avoid freeze-thaw cycles.
Database Links Reactome: R-HSA-8874211
Alternative Names Anti-Dendritic Cell-Specific Transmembrane Protein antibody
Anti-Dc-Stamp antibody
Anti-Hdc-Stamp antibody
Anti-Dendrocyte-Expressed Seven Transmembrane Protein antibody
Anti-Il-Four-Induced Protein antibody
Anti-Find antibody
Anti-Transmembrane 7 Superfamily Member 4 antibody
Anti-DCSTAMP TM7SF4 antibody
Function Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.
Cellular Localization Cell Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Localizes To The Cell Surface In Osteoclasts And Undifferentiated Monocytes
Intracellular Internalized Dcstamp Is Detected In A Fraction Of Rankl-Induced Osteoclast Precursor
Colocalizes With Os9 In The Endoplasmic Reticulum (Er) Of Immature Dendritic Cell (Dc)
Translocates From The Endoplasmic Reticulum To The Intermediate/Golgi Compartment Upon Maturation Of Dc In A Os9-Dependent Manner
Colocalizes With Lamp1 In Endosomes
Post-translational Modifications Glycosylated.

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