Human Angiotensin I ELISA kit

[STJ150529] Download PDF Print Data Sheet

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Product name Human Angiotensin I ELISA kit
Short Description Human ELISA Kit to Ang-I.
Description The kit is a competitive enzyme immunoassay for in vitro quantitative measurement of Ang-I in Human serum, plasma and other biological fluids.
Applications ELISA
Dilution range 125--8000pg/mL
Protein Name Ang-I
Storage Instruction Store at 4°C for 6 months.
Validated Application ELISA
Reactivity Human
Gene ID 183
Gene Symbol AGT
Molecular Weight 41.1 kDa
Database Links HGNC:336
Alternative Names Angiotensinogen, Serpin A8 [Cleaved Into-Angiotensin-1, Angiotensin 1-10, Angiotensin I, Ang I-Angiotensin-2, Angiotensin 1-8, Angiotensin Ii, Ang Ii-Angiotensin-3, Angiotensin 2-8, Angiotensin Iii, Ang Iii, Des-Asp[1]-Angiotensin Ii-Angiotensin-4, Angiotensin 3-8, Angiotensin Iv, Ang Iv-Angiotensin 1-9-Angiotensin 1-7-Angiotensin 1-5-Angiotensin 1-4]
Function Essential component of the renin-angiotensin system (RAS) , a potent regulator of blood pressure, body fluid and electrolyte homeostasis.; [Angiotensin-2]: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.; [Angiotensin-3]: stimulates aldosterone release.; [Angiotensin 1-7]: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
Post-translational Modifications Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.; In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin) .; The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.
Cellular Localization Secreted
Tissue Specificity Serum, Plasma, Biological Fluids
Swiss-Prot Key ANGT_HUMAN
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