Human Mucin 2 ELISA kit

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Product name Human Mucin 2 ELISA kit
Short Description Human ELISA Kit to MUC2.
Description The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of MUC2 in Human serum, plasma and other biological fluids.
Applications ELISA
Dilution range 0.313--20ng/mL
Protein Name MUC2
Storage Instruction Store at 4°C for 6 months.
Note FOR RESEARCH USE ONLY (RUO) .
Validated Application ELISA
Reactivity Human
Gene Symbol MUC2
Molecular Weight 540.3 kDa
Database Links HGNC:7512
OMIM:158370
Reactome:R-HSA-5083625
Alternative Names Mucin-2, Muc-2, Intestinal Mucin-2
Function Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
Post-translational Modifications O-glycosylated.; May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.; At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.
Cellular Localization Secreted, Note=In The Intestine, Secreted Into The Inner And Outer Mucus Layers
Tissue Specificity Serum, Plasma, Biological Fluids
Swiss-Prot Key MUC2_HUMAN
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