Human S100 Calcium Binding Protein B ELISA kit

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Product name Human S100 Calcium Binding Protein B ELISA kit
Short Description Human ELISA Kit to S100B.
Description The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of S100B in Human serum, plasma and other biological fluids.
Applications ELISA
Dilution range 31.25--2000pg/mL
Protein Name S100B
Storage Instruction Store at 4°C for 6 months.
Note For Research Use Only (RUO) .
Validated Application ELISA
Reactivity Human
Gene ID 6285
Gene Symbol S100B
Molecular Weight 10.7 kDa
Database Links HGNC:10500
OMIM:176990
Reactome:R-HSA-1251985
Alternative Names Protein S100-B, S-100 Protein Beta Chain, S-100 Protein Subunit Beta, S100 Calcium-Binding Protein B
Function Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
Cellular Localization Cytoplasm, Nucleus
Tissue Specificity Serum, Plasma, Biological Fluids
Swiss-Prot Key S100B_HUMAN
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