[STJ150548] Download PDF Print Data Sheet

* Required Fields

Product name Mouse AATF ELISA Kit
Short Description Mouse ELISA Kit to AATF
Description The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of AATF in Mouse serum, plasma and other biological fluids
Applications ELISA
Dilution range 31.25--2000pg/mL
Protein Name Protein AATF
Apoptosis-antagonizing transcription factor
Rb-binding protein Che-1
Storage Instruction Store at 4°C for 6 months.
Note For Research Use Only (RUO).
Validated Application ELISA
Conjugation Unconjugated
Concentration 2000pg/mL
Gene ID 26574
Gene Symbol AATF
Molecular Weight 63.1 kDa
Database Links HGNC:19235
Alternative Names Protein AATF
Apoptosis-antagonizing transcription factor
Rb-binding protein Che-1
Function May function as a general inhibitor of the histone deacetylase HDAC1, Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression, Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression, Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Post-translational Modifications Hyperphosphorylated during the G1/S phase transition
Cellular Localization Nucleus, nucleolus
Tissue Specificity Serum, Plasma, Biological Fluids
Swiss-Prot Key Q9NY61
Bad Good
Enter the code in the box below:

Ask us a question

No questions yet. Be the first to ask the question!


Use spaces to separate tags. Use single quotes (') for phrases.