[STJ150553] Download PDF Print Data Sheet

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Product name Mouse INHBA ELISA Kit
Short Description Mouse ELISA Kit to INHBA
Description The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of ACV-A in Mouse serum, plasma and other biological fluids
Applications ELISA
Dilution range 78.125--5000pg/mL
Protein Name Inhibin beta A chain
Activin beta-A chain
Erythroid differentiation protein
Storage Instruction Store at 4°C for 6 months.
Note For Research Use Only (RUO).
Validated Application ELISA
Conjugation Unconjugated
Concentration 5000pg/mL
Gene ID 3624
Gene Symbol INHBA
Molecular Weight 56 kDa
Database Links HGNC:6066
Alternative Names Inhibin beta A chain
Activin beta-A chain
Erythroid differentiation protein
Function Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3, Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis, The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2, Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4, The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes, This constitutes the canonical SMAD-dependent TGF-beta signaling cascade, Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways, For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis, Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.
Post-translational Modifications Phosphorylated at basal levels in the absence of ligand, Activated upon phosphorylation by TGFBR2, mainly in the GS domain, Phosphorylation in the GS domain abrogates FKBP1A-binding,
Cellular Localization Secreted
Tissue Specificity Serum, Plasma, Biological Fluids
Swiss-Prot Key P08476
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