Rat LCN2 ELISA Kit

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Product name Rat LCN2 ELISA Kit
Short Description Rat ELISA Kit to LCN2
Description The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of NGAL in Rat serum, plasma and other biological fluids
Applications ELISA
Dilution range 62.5--4000pg/mL
Protein Name Neutrophil gelatinase-associated lipocalin
NGAL
25 kDa alpha-2-microglobulin-related subunit of MMP-9
Lipocalin-2
Oncogene 24p3
Siderocalin LCN2
p25
Storage Instruction Store at 4°C for 6 months.
Note FOR RESEARCH USE ONLY (RUO) .
Validated Application ELISA
Reactivity Rat
Conjugation Unconjugated
Concentration 4000pg/mL
Gene ID 3934
Gene Symbol LCN2
Molecular Weight 22.6 kDa
Database Links HGNC:6526
OMIM:600181
Reactome:R-HSA-6785807
Alternative Names Neutrophil gelatinase-associated lipocalin
NGAL
25 kDa alpha-2-microglobulin-related subunit of MMP-9
Lipocalin-2
Oncogene 24p3
Siderocalin LCN2
p25
Function Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development, Binds iron through association with 2, 5-dihydroxybenzoic acid (2, 5-DHBA) , a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context, Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration, In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration, Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis, Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
Cellular Localization Secreted
Tissue Specificity Serum, Plasma, Biological Fluids
Swiss-Prot Key P80188
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