Human Carbohydrate Antigen 125 ELISA kit

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Product name Human Carbohydrate Antigen 125 ELISA kit
Short Description Human ELISA Kit to CA125.
Description The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of CA125 in Human serum, plasma and other biological fluids.
Applications ELISA
Dilution range 3.125--200U/mL
Protein Name CA125
Storage Instruction Store at 4°C for 6 months.
Note FOR RESEARCH USE ONLY (RUO) .
Validated Application ELISA
Reactivity Human
Gene ID 94025
Gene Symbol MUC16
Molecular Weight 1519.2 kDa
Database Links HGNC:15582
OMIM:606154
Reactome:R-HSA-5083625
Alternative Names Mucin-16, Muc-16, Ovarian Cancer-Related Tumor Marker Ca125, Ca-125, Ovarian Carcinoma Antigen Ca125
Function Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
Post-translational Modifications Heavily O-glycosylated; expresses both type 1 and type 2 core glycans.; Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans.; May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space.; May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.
Cellular Localization Cell Membrane, Single-Pass Type I Membrane Protein, Secreted, Extracellular Space, Note=May Be Liberated Into The Extracellular Space Following The Phosphorylation Of The Intracellular C-Terminus Which Induces The Proteolytic Cleavage And Liberation Of The Extracellular Domain
Tissue Specificity Serum, Plasma, Biological Fluids
Swiss-Prot Key MUC16_HUMAN
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