Human Cyclophilin A ELISA kit

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Product name Human Cyclophilin A ELISA kit
Short Description Human ELISA Kit to CYPA.
Description The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of CYPA in Human serum, plasma and other biological fluids.
Applications ELISA
Dilution range 1.25--80ng/mL
Protein Name CYPA
Storage Instruction Store at 4°C for 6 months.
Note FOR RESEARCH USE ONLY (RUO) .
Validated Application ELISA
Reactivity Human
Gene ID 5478
Gene Symbol PPIA
Molecular Weight 18 kDa
Database Links HGNC:9253
OMIM:123840
Reactome:R-HSA-114608
Alternative Names Peptidyl-Prolyl Cis-Trans Isomerase A, Ppiase A, Cyclophilin A, Cyclosporin A-Binding Protein, Rotamase A [Cleaved Into-Peptidyl-Prolyl Cis-Trans Isomerase A-N-Terminally Processed]
Function PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Post-translational Modifications Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition.
Cellular Localization Cytoplasm, Secreted, Note=Secretion Occurs In Response To Oxidative Stress In Vascular Smooth Muscle Through A Vesicular Secretory Pathway That Involves Actin Remodeling And Myosin Ii Activation, And Mediates Erk1/2 Activation
Tissue Specificity Serum, Plasma, Biological Fluids
Swiss-Prot Key PPIA_HUMAN
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