Human Fibroblast Growth Factor 23 ELISA kit

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Product name Human Fibroblast Growth Factor 23 ELISA kit
Short Description Human ELISA Kit to FGF23.
Description The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of FGF23 in Human serum, plasma and other biological fluids.
Applications ELISA
Dilution range 15.625--1000pg/mL
Protein Name FGF23
Storage Instruction Store at 4°C for 6 months.
Validated Application ELISA
Reactivity Human
Gene ID 8074
Gene Symbol FGF23
Molecular Weight 28 kDa
Database Links HGNC:3680
Alternative Names Fibroblast Growth Factor 23, Fgf-23, Phosphatonin, Tumor-Derived Hypophosphatemia-Inducing Factor [Cleaved Into-Fibroblast Growth Factor 23 N-Terminal Peptide-Fibroblast Growth Factor 23 C-Terminal Peptide]
Function Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL. Acts directly on the parathyroid to decrease PTH secretion. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.
Post-translational Modifications Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The processing is effected by proprotein convertases.; O-glycosylated by GALT3. Glycosylation is necessary for secretion; it blocks processing by proprotein convertases when the O-glycan is alpha 2, 6-sialylated. Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23.
Cellular Localization Secreted, Note=Secretion Is Dependent On O-Glycosylation
Tissue Specificity Serum, Plasma, Biological Fluids
Swiss-Prot Key FGF23_HUMAN
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