Human Angiogenin ELISA kit

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Product name Human Angiogenin ELISA kit
Short Description Human ELISA Kit to ANG.
Description The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of ANG in Human serum, plasma and other biological fluids.
Applications ELISA
Dilution range 15.625--1000pg/mL
Protein Name ANG
Storage Instruction Store at 4°C for 6 months.
Note FOR RESEARCH USE ONLY (RUO) .
Validated Application ELISA
Reactivity Human
Gene ID 283
Gene Symbol ANG
Molecular Weight 16.6 kDa
Database Links HGNC:483
OMIM:105850
Reactome:R-HSA-418990
Alternative Names Angiogenin, Ribonuclease 5, Rnase 5
Function Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) . Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Cellular Localization Cytoplasmic Vesicle, Secretory Vesicle Lumen, Secreted, Nucleus, Nucleolus, Note=Rapidly Endocytosed By Target Cells And Translocated To The Nucleus Where It Accumulates In The Nucleolus And Binds To Dna (Pubmed:12051708)
Tissue Specificity Serum, Plasma, Biological Fluids
Swiss-Prot Key ANGI_HUMAN
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