Human Annexin A1 ELISA kit

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Product name Human Annexin A1 ELISA kit
Short Description Human ELISA Kit to ANXA1.
Description The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of ANXA1 in Human serum, plasma and other biological fluids.
Applications ELISA
Dilution range 0.313--20ng/mL
Protein Name ANXA1
Storage Instruction Store at 4°C for 6 months.
Validated Application ELISA
Reactivity Human
Gene ID 301
Gene Symbol ANXA1
Molecular Weight 38.7 kDa
Database Links HGNC:533
Alternative Names Annexin A1, Annexin I, Annexin-1, Calpactin Ii, Calpactin-2, Chromobindin-9, Lipocortin I, Phospholipase A2 Inhibitory Protein, P35
Function Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing. Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells. Has no effect on unstimulated T cells. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton. Has high affinity for Ca (2+) and can bind up to eight Ca (2+) ions. Displays Ca (2+) -dependent binding to phospholipid membranes. Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca (2+) -dependent interaction between phagosomes and the actin cytoskeleton.
Post-translational Modifications Phosphorylated by protein kinase C, EGFR and TRPM7. Phosphorylated in response to EGF treatment.; Sumoylated.
Cellular Localization Nucleus, Cytoplasm, Cell Projection, Cilium, Cell Membrane, Membrane, Peripheral Membrane Protein, Endosome Membrane, Basolateral Cell Membrane, Apical Cell Membrane, Lateral Cell Membrane, Secreted, Extracellular Space, Extracellular Side, Extracellular Exosome, Cytoplasmic Vesicle, Secretory Vesicle Lumen, Phagocytic Cup, Early Endosome, Cytoplasmic Vesicle Membrane, Note=Secreted, At Least In Part Via Exosomes And Other Secretory Vesicles, Detected In Exosomes And Other Extracellular Vesicles (Pubmed:25664854) , Detected In Gelatinase Granules In Resting Neutrophils (Pubmed:10772777) , Secretion Is Increased In Response To Wounding And Inflammation (Pubmed:25664854) , Secretion Is Increased Upon T-Cell Activation (Pubmed:17008549) , Neutrophil Adhesion To Endothelial Cells Stimulates Secretion Via Gelatinase Granules, But Foreign Particle Phagocytosis Has No Effect (Pubmed:10772777) , Colocalizes With Actin Fibers At Phagocytic Cups (By Similarity) , Displays Calcium-Dependent Binding To Phospholipid Membranes (Pubmed:2532504, Pubmed:8557678)
Tissue Specificity Serum, Plasma, Biological Fluids
Swiss-Prot Key ANXA1_HUMAN
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