Human Apelin ELISA kit

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Product name Human Apelin ELISA kit
Short Description Human ELISA Kit to APLN.
Description The kit is a competitive enzyme immunoassay for in vitro quantitative measurement of APLN in Human serum, plasma and other biological fluids.
Applications ELISA
Dilution range 62.5--4000pg/mL
Protein Name APLN
Storage Instruction Store at 4°C for 6 months.
Note FOR RESEARCH USE ONLY (RUO) .
Validated Application ELISA
Reactivity Human
Gene ID 8862
Gene Symbol APLN
Molecular Weight 42.7 kDa
Database Links HGNC:339
OMIM:600052
Reactome:R-HSA-375276
Alternative Names Apelin, Apj Endogenous Ligand [Cleaved Into-Apelin-36-Apelin-31-Apelin-28-Apelin-13]
Function Endogenous ligand for the apelin receptor (APLNR) . Drives internalization of the apelin receptor. Apelin-36 dissociates more hardly than (pyroglu) apelin-13 from APLNR. Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis. Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates. Plays a role in early coronary blood vessels formation. Mediates myocardial contractility in an ERK1/2-dependent manner. May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior.; (Microbial infection) Endogenous ligand for the apelin receptor (APLNR) , an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APLNR. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives.
Post-translational Modifications Several active peptides may be produced by proteolytic processing of the peptide precursor.
Cellular Localization Secreted, Extracellular Space, Note=Abundantly Secreted In The Colostrum, Lower Level In Milk, Decreases Rapidly Within Several Days After Parturition In Milk, But Is Still Detectable Even In Commercial Milk
Tissue Specificity Serum, Plasma, Biological Fluids
Swiss-Prot Key APEL_HUMAN
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