Human Bcl-2(B-cell Leukemia/Lymphoma 2) ELISA Kit

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Product name Human Bcl-2(B-cell Leukemia/Lymphoma 2) ELISA Kit
Short Description Human ELISA Kit to Bcl-2
Description The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of Bcl-2 in human serum, plasma and other biological fluids
Applications ELISA
Dilution range 0.156--10ng/mL
Protein Name B-cell leukemia/lymphoma 2
B-cell leukemia/lymphoma 2
isoform CRA_a
Storage Instruction Store at 4°C for 6 months.
Note For Research Use Only (RUO).
Validated Application ELISA
Conjugation Unconjugated
Concentration 10ng/mL
Gene ID 12043
Molecular Weight 26.3 kDa
Alternative Names B-cell leukemia/lymphoma 2
B-cell leukemia/lymphoma 2
isoform CRA_a
Function Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells, Regulates cell death by controlling the mitochondrial membrane permeability, Appears to function in a feedback loop system with caspases, Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1), May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release .
Post-translational Modifications Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity, Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle, In the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases, Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-87, wich stimulates starvation-induced autophagy, Dephosphorylated by protein phosphatase 2A (PP2A) ,
Tissue Specificity Serum, Plasma, Biological Fluids
Swiss-Prot Key Q6NTH7
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