Human Brain Derived Neurotrophic Factor ELISA kit

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Product name Human Brain Derived Neurotrophic Factor ELISA kit
Short Description Human ELISA Kit to BDNF.
Description The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of BDNF in Human serum, plasma and other biological fluids.
Applications ELISA
Dilution range 31.25--2000pg/mL
Protein Name BDNF
Storage Instruction Store at 4°C for 6 months.
Validated Application ELISA
Reactivity Human
Gene ID 627
Gene Symbol BDNF
Molecular Weight 27.8 kDa
Database Links HGNC:1033
Alternative Names Brain-Derived Neurotrophic Factor, Bdnf, Abrineurin [Cleaved Into-Bdnf Precursor Form, Probdnf]
Function Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP) , long-term depression (LTD) , certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.; [BDNF precursor form]: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD) . Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse.
Post-translational Modifications [BDNF precursor form]: N-glycosylated and glycosulfated, contrary to mature BDNF.; Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF. Can be converted into mature BDNF by plasmin (PLG) .
Cellular Localization Secreted, Bdnf Precursor Form: Secreted, Note=A Proportion Of Bdnf Is Secreted As Immature Precursor (Probdnf)
Tissue Specificity Serum, Plasma, Biological Fluids
Swiss-Prot Key BDNF_HUMAN
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