Human EPOR ELISA Kit

[STJ150243] Download PDF Print Data Sheet
Product name Human EPOR ELISA Kit
Short Description Human ELISA Kit to EPOR
Description The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of EPO in human serum, plasma and other biological fluids
Applications ELISA
Dilution range 31.25--2000pg/mL
Protein Name Erythropoietin receptor
EPO-R
Storage Instruction Store at 4°C for 6 months.
Note For Research Use Only (RUO).
Validated Application ELISA
Conjugation Unconjugated
Concentration 2000pg/mL
Gene ID 2057
Gene Symbol EPOR
Molecular Weight 55.1 kDa
Database Links HGNC:3416
OMIM:133100
Alternative Names Erythropoietin receptor
EPO-R
Function Receptor for erythropoietin, Mediates erythropoietin-induced erythroblast proliferation and differentiation, Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade, In some cell types, can also activate STAT1 and STAT3, May also activate the LYN tyrosine kinase.
Post-translational Modifications On EPO stimulation, phosphorylated on C-terminal tyrosine residues by JAK2, The phosphotyrosine motifs are also recruitment sites for several SH2-containing proteins and adapter proteins which mediate cell proliferation, Phosphorylation on Tyr-454 is required for PTPN6 interaction, Tyr-426 for PTPN11, Tyr-426 is also required for SOCS3 binding, but Tyr-454/Tyr-456 motif is the preferred binding site,
Cellular Localization Cell membrane
Tissue Specificity Serum, Plasma, Biological Fluids
Swiss-Prot Key P19235
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