ESR1 ELISA Kit

[STJ150093] Download PDF Print Data Sheet

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Product name ESR1 ELISA Kit
Short Description ELISA Kit to ESR1
Description The kit is a competitive enzyme immunoassay for in vitro quantitative measurement of E2 in serum, plasma and other biological fluids
Applications ELISA
Dilution range 21.875--1400pg/mL
Protein Name Estrogen receptor
ER
ER-alpha
Estradiol receptor
Nuclear receptor subfamily 3 group A member 1
Storage Instruction Store at 4°C for 6 months.
Note FOR RESEARCH USE ONLY (RUO) .
Validated Application ELISA
Reactivity ESR1ELISAKit
Conjugation Unconjugated
Concentration 1400pg/mL
Gene ID 2099
Gene Symbol ESR1
Molecular Weight 66.2 kDa
Database Links HGNC:3467
OMIM:133430
Reactome:R-HSA-1251985
Alternative Names Estrogen receptor
ER
ER-alpha
Estradiol receptor
Nuclear receptor subfamily 3 group A member 1
Function Nuclear hormone receptor, The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling, Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components, Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner, Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter, Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP, Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences, Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements.
Post-translational Modifications Phosphorylated by cyclin A/CDK2 and CK1, Phosphorylation probably enhances transcriptional activity, Self-association induces phosphorylation, Dephosphorylation at Ser-118 by PPP5C inhibits its transactivation activity, Phosphorylated by LMTK3 in vitro
Cellular Localization Nucleus, Nucleus, Golgi apparatus, Cell membrane
Tissue Specificity Serum, Plasma, Biological Fluids
Swiss-Prot Key P03372
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