Anti-ABCA1 Antibody

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Product name Anti-ABCA1 Antibody
Short Description Rabbit polyclonal against ABCA1
Description The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name ATP-binding cassette sub-family A member 1
ATP-binding cassette transporter 1
ABC-1
ATP-binding cassette 1
Cholesterol efflux regulatory protein
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1870-2120 of human ABCA1 (NP_005493.2).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 19
Gene Symbol ABCA1
Molecular Weight 254.302 kDa
Database Links HGNC:29
OMIM:205400
Reactome:R-HSA-1989781
Alternative Names ATP-binding cassette sub-family A member 1
ATP-binding cassette transporter 1
ABC-1
ATP-binding cassette 1
Cholesterol efflux regulatory protein
Function cAMP-dependent and sulfonylurea-sensitive anion transporter, Key gatekeeper influencing intracellular cholesterol transport
Post-translational Modifications Phosphorylation on Ser-2054 regulates phospholipid efflux,
Cellular Localization Membrane
Tissue Specificity Widely expressed, but most abundant in macrophages
Swiss-Prot Key O95477
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