Anti-ABCA1 antibody

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Product name Anti-ABCA1 antibody
Short Description Rabbit polyclonal against ABCA1
Description The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
Applications WB
Dilution range WB 1:500-1:2000
Protein Name Phospholipid-Transporting Atpase Abca1
Atp-Binding Cassette Sub-Family A Member 1
Atp-Binding Cassette Transporter 1
Abc-1
Atp-Binding Cassette 1
Cholesterol Efflux Regulatory Protein
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1870-2120 of human ABCA1 (NP_005493. 2).
Storage Instruction Store at-20°C and avoid freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 19
Gene Symbol ABCA1
Molecular Weight Calculated: 254kDa. Observed: 254kDa
Database Links Reactome: R-HSA-1989781
Alternative Names Anti-Phospholipid-Transporting Atpase Abca1 antibody
Anti-Atp-Binding Cassette Sub-Family A Member 1 antibody
Anti-Atp-Binding Cassette Transporter 1 antibody
Anti-Abc-1 antibody
Anti-Atp-Binding Cassette 1 antibody
Anti-Cholesterol Efflux Regulatory Protein antibody
Anti-ABCA1 ABC1 CERP antibody
Function Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates to phospholipids transfer to apoliproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apoliproteins and the formation of nascent high density lipoproteins/HDLs.
Post-translational Modifications Phosphorylation on Ser-2054 regulates phospholipid efflux. Palmitoylation by DHHC8 is essential for membrane localization.
Cellular Localization Membrane
Multi-Pass Membrane Protein
Cell Membrane
Endosome
Tissue Specificity Widely expressed, but most abundant in macrophages.
Swiss-Prot Key ABCA1_HUMAN
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