Anti-ABCC4 antibody (1067-1325) (STJ22460)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MRP4/ABCC4 (1067-1325) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ABCC4 |
| Gene ID | 10257 |
| Uniprot ID | MRP4_HUMAN |
| Immunogen Region | 1067-1325 |
| Immunogen Sequence | SQEKVGIVGRTGAGKSSLIS ALFRLSEPEGKIWIDKILTT EIGLHDLRKKMSIIPQEPVL FTGTMRKNLDPFNEHTDEEL WNALQEVQLKETIEDLPGKM DTELAESGSNFSVGQRQLVC LARAILRKNQILIIDEATAN VDPRTDELIQKKIREKFAHC TVLTIAHRLNTIIDSDKIMV LDSGRLKEYDEPYVLLQNKE SLFYKMVQQLGKAEAAALTE TAKQVYFKRNYPHIGHTDH |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1067-1325 of human MRP4/ABCC4 (NP_005836.2). |
Additional Info
| Tissue Specificity | Widely expressed, with particularly high levels in prostate, but is barely detectable in liver. sinusoidal membrane of hepatocytes. |
| Post Translational Modifications | N-glycosylated.leading to substrate-selective effects on its transport activity. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Confers resistance to anticancer agents such as methotrexate. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 4 Mrp/Cmoat-Related Abc TransporterMulti-Specific Organic Anion Transporter BMoat-BMultidrug Resistance-Associated Protein 4 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-382556Reactome: R-HSA-9748787Reactome: R-HSA-9753281 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneIts Localization To The Basolateral Or Apical Membranes Is Tissue-Dependent |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 4 antibodyAnti-Mrp/Cmoat-Related Abc Transporter antibodyAnti-Multi-Specific Organic Anion Transporter B antibodyAnti-Moat-B antibodyAnti-Multidrug Resistance-Associated Protein 4 antibodyAnti-ABCC4 antibodyAnti-MOATB antibodyAnti-MRP4 antibody |
Information sourced from Uniprot.org