Anti-ABCG2 antibody

[STJ97253] Download PDF Print Data Sheet

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Product name Anti-ABCG2 antibody
Short Description Rabbit polyclonal against ABCG2
Description ABCG2 is a protein encoded by the ABCG2 gene which is approximately 72,3 kDa. ABCG2 is localised to the cell membrane and mitochondrion membrane. It is involved in the Gefitinib pathway, Irinotecan pathway, and pyrimidine metabolism. It is a high-capacity urate exporter functioning in both renal and extrarenal urate excretion. It plays a role in porphyrin homeostasis as it is able to mediate the export of protoporhyrin IX both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. ABCG2 is highly expressed in the placenta. Mutations in the ABCG2 gene may result in erythroplakia and hyperuricemia. STJ97253 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of ABCG2 protein.
Applications ELISA, IHC, WB
Dilution range WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:10000
Specificity ABCG2 Polyclonal Antibody detects endogenous levels of ABCG2 protein.
Protein Name ATP-binding cassette sub-family G member 2
Breast cancer resistance protein
CDw338
Mitoxantrone resistance-associated protein
Placenta-specific ATP-binding cassette transporter
Urate exporter
CD antigen CD338
Immunogen Synthesized peptide derived from human ABCG2.
Immunogen Region 461-510 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application IF IHC WB
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 9429
Gene Symbol ABCG2
Database Links HGNC:74
OMIM:138900
Alternative Names ATP-binding cassette sub-family G member 2
Breast cancer resistance protein
CDw338
Mitoxantrone resistance-associated protein
Placenta-specific ATP-binding cassette transporter
Urate exporter
CD antigen CD338
Function High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
Post-translational Modifications Glycosylation-deficient ABCG2 is normally expressed and functional.
Cellular Localization Cell membrane Mitochondrion membrane
Tissue Specificity Highly expressed in placenta. Low expression in small intestine, liver and colon.
Sequence and Domain Family The extracellular loop 3 (ECL3) is involved in binding porphyrins and transfer them to other carriers, probably albumin.
Swiss-Prot Key Q9UNQ0_HUMAN
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