Anti-ABCG2 antibody

[STJ97253] Download PDF Print Data Sheet

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Product name Anti-ABCG2 antibody
Short Description Rabbit polyclonal against ABCG2
Description ABCG2 is a protein encoded by the ABCG2 gene which is approximately 72, 3 kDa. ABCG2 is localised to the cell membrane and mitochondrion membrane. It is involved in the Gefitinib pathway, Irinotecan pathway, and pyrimidine metabolism. It is a high-capacity urate exporter functioning in both renal and extrarenal urate excretion. It plays a role in porphyrin homeostasis as it is able to mediate the export of protoporhyrin IX both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. ABCG2 is highly expressed in the placenta. Mutations in the ABCG2 gene may result in erythroplakia and hyperuricemia. STJ97253 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of ABCG2 protein.
Applications ELISA, IF, IHC-p, WB
Dilution range IF 1:50-200
WB 1:500-1:2000
IHC-p 1:100-1:300
ELISA 1:10000
Specificity ABCG2 polyclonal antibody detects endogenous levels of ABCG2 protein.
Protein Name Broad Substrate Specificity Atp-Binding Cassette Transporter Abcg2
Atp-Binding Cassette Sub-Family G Member 2
Breast Cancer Resistance Protein
Cdw338
Mitoxantrone Resistance-Associated Protein
Placenta-Specific Atp-Binding Cassette Transporter
Urate Exporter
Cd Antigen Cd338
Immunogen Synthesized peptide derived from human ABCG2.
Immunogen Region 461-510 aa, Internal
Storage Instruction Store at-20°C, and avoid repeat freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 9429
Gene Symbol ABCG2
Database Links HGNC:74
OMIM:138900
Alternative Names Anti-Broad Substrate Specificity Atp-Binding Cassette Transporter Abcg2 antibody
Anti-Atp-Binding Cassette Sub-Family G Member 2 antibody
Anti-Breast Cancer Resistance Protein antibody
Anti-Cdw338 antibody
Anti-Mitoxantrone Resistance-Associated Protein antibody
Anti-Placenta-Specific Atp-Binding Cassette Transporter antibody
Anti-Urate Exporter antibody
Anti-Cd Antigen Cd338 antibody
Anti-ABCG2 ABCP BCRP BCRP1 MXR antibody
Function Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion. In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate. Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates. Mediates the secretion of the riboflavin and biotin vitamins into milk. Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability. Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux. In placenta, it limits the penetration of drugs from the maternal plasma into the fetus. May play a role in early stem cell self-renewal by blocking differentiation.
Post-translational Modifications N-glycosylated. Glycosylation-deficient ABCG2 is normally expressed and functional.; Phosphorylated. Phosphorylation at Thr-362 by PIM1 is induced by drugs like mitoxantrone and is associated with cells increased drug resistance. It regulates the localization to the plasma membrane, the homooligomerization and therefore, the activity of the transporter.
Cellular Localization Cell Membrane
Multi-Pass Membrane Protein
Apical Cell Membrane
Mitochondrion Membrane
Enriched In Membrane Lipid Rafts
Tissue Specificity Highly expressed in placenta. Low expression in small intestine, liver and colon. Expressed in brain (at protein level).
Swiss-Prot Key ABCG2_HUMAN
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