| Function | In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs. Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage. |
| Protein Name | 3-Ketoacyl-Coa Thiolase - MitochondrialAcetyl-Coa AcetyltransferaseAcetyl-Coa AcyltransferaseAcyl-Coa Hydrolase - MitochondrialBeta-KetothiolaseMitochondrial 3-Oxoacyl-Coa ThiolaseT1 |
| Database Links | Reactome: R-HSA-77289 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-3-Ketoacyl-Coa Thiolase - Mitochondrial antibodyAnti-Acetyl-Coa Acetyltransferase antibodyAnti-Acetyl-Coa Acyltransferase antibodyAnti-Acyl-Coa Hydrolase - Mitochondrial antibodyAnti-Beta-Ketothiolase antibodyAnti-Mitochondrial 3-Oxoacyl-Coa Thiolase antibodyAnti-T1 antibodyAnti-ACAA2 antibody |
Information sourced from Uniprot.org
