| Tissue Specificity | Expressed in pancreas, placenta, liver, heart, brain, kidney, skeletal muscle, and lung. |
| Function | Dolichyl-phosphate beta-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Dolichyl-phosphate beta-glucosyltransferase produces dolichyl beta-D-glucosyl phosphate/Dol-P-Glc, the glucose donor substrate used sequentially by ALG6, ALG8 and ALG10 to add glucose residues on top of the Man(9)GlcNAc(2)-PP-Dol structure. These are the three last steps in the biosynthetic pathway of dolichol-linked oligosaccharides to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol. The enzyme is most probably active on the cytoplasmic side of the endoplasmic reticulum while its product Dol-P-Glc is the substrate for ALG6, ALG8 and ALG11 in the lumen of the endoplasmic reticulum. |
| Protein Name | Dolichyl-Phosphate Beta-GlucosyltransferaseDolp-GlucosyltransferaseAsparagine-Linked Glycosylation Protein 5 Homolog |
| Database Links | Reactome: R-HSA-480985 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Dolichyl-Phosphate Beta-Glucosyltransferase antibodyAnti-Dolp-Glucosyltransferase antibodyAnti-Asparagine-Linked Glycosylation Protein 5 Homolog antibodyAnti-ALG5 antibodyAnti-HSPC149 antibody |
Information sourced from Uniprot.org
