Anti-ANKLE2 antibody (350-450) (STJ119707)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ANKLE2 (350-450) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ANKLE2 |
| Gene ID | 23141 |
| Uniprot ID | ANKL2_HUMAN |
| Immunogen Region | 350-450 |
| Immunogen Sequence | CRYNVMHVAAKENQASICQL TLDVLENPDFMRLMYPDDDE AMLQKRIRYVVDLYLNTPDK MGYDTPLHFACKFGNADVVN VLSSHHLIVKNSRNKYDKTP E |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 350-450 of human ANKLE2 (NP_055929.1). |
Additional Info
| Function | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. May regulate nuclear localization of VRK1 in non-dividing cells. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development. |
| Protein Name | Ankyrin Repeat And Lem Domain-Containing Protein 2Lem Domain-Containing Protein 4 |
| Database Links | Reactome: R-HSA-2995383Reactome: R-HSA-9013404Reactome: R-HSA-9013408 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iii Membrane Protein |
| Alternative Antibody Names | Anti-Ankyrin Repeat And Lem Domain-Containing Protein 2 antibodyAnti-Lem Domain-Containing Protein 4 antibodyAnti-ANKLE2 antibodyAnti-KIAA0692 antibodyAnti-LEM4 antibody |
Information sourced from Uniprot.org