| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Ankyrin repeat and sterile alpha motif domain-containing protein 1B is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ANKS1B |
| Gene ID: | 56899 |
| Uniprot ID: | ANS1B_HUMAN |
| Specificity: | This antibody detects endogenous levels of ANKS1B at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human ANKS1B |
| Post Translational Modifications | Isoform 3 nuclear translocation requires an NMDAR-dependent proteolytic cleavage. |
| Function | Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing. |
| Protein Name | Ankyrin Repeat And Sterile Alpha Motif Domain-Containing Protein 1b Amyloid-Beta Protein Intracellular Domain-Associated Protein 1 Aida-1 E2a-Pbx1-Associated Protein Eb-1 |
| Cellular Localisation | Cytoplasm Isoform 2: Nucleus Isoform 3: Postsynaptic Density Cell Projection Dendritic Spine Nucleus Cajal Body The Synaptic Localization Requires Dlg4 Interaction Translocation To The Nucleus In Response To Stimulation Of Nmda Receptors (Nmdars) In A Calcium-Independent Manner Isoform 4: Nucleus The Interaction With App Causes Its Partial Exclusion From The Nucleus When App Is Overexpressed Isoform 6: Nucleus |
| Alternative Antibody Names | Anti-Ankyrin Repeat And Sterile Alpha Motif Domain-Containing Protein 1b antibody Anti-Amyloid-Beta Protein Intracellular Domain-Associated Protein 1 antibody Anti-Aida-1 antibody Anti-E2a-Pbx1-Associated Protein antibody Anti-Eb-1 antibody Anti-ANKS1B antibody |
Information sourced from Uniprot.org