| Function | Involved in pre-mRNA splicing as component of the spliceosome. Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro). |
| Protein Name | Rna Helicase AquariusIntron-Binding Protein Of 160 KdaIbp160 |
| Database Links | Reactome: R-HSA-6781823Reactome: R-HSA-6781827Reactome: R-HSA-6782135Reactome: R-HSA-6782210Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleoplasmLocalizes To Speckle-Like Regions Of The Nucleoplasm |
| Alternative Antibody Names | Anti-Rna Helicase Aquarius antibodyAnti-Intron-Binding Protein Of 160 Kda antibodyAnti-Ibp160 antibodyAnti-AQR antibodyAnti-KIAA0560 antibody |
Information sourced from Uniprot.org
