| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | ATRN |
| Gene ID: | 8455 |
| Uniprot ID: | ATRN_HUMAN |
| Immunogen Region: | 84-350 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 84-350 of human ATRN (NP_647538.1). |
| Immunogen Sequence: | AAAAAAVSGSAAAEAKECDR PCVNGGRCNPGTGQCVCPAG WVGEQCQHCGGRFRLTGSSG FVTDGPGNYKYKTKCTWLIE GQPNRIMRLRFNHFATECSW DHLYVYDGDSIYAPLVAAFS GLIVPERDGNETVPEVVATS GYALLHFFSDAAYNLTGFNI TYSFDMCPNNCSGRGECKIS NSSDTVECECSENWKGEACD IPHCTDNCGFPHRGICNSSD VRGCSCFSDWQGPGCSVPV |
| Tissue Specificity | Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes. |
| Post Translational Modifications | Heavily glycosylated. |
| Function | Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti. Has a critical role in normal myelination in the central nervous system. |
| Protein Name | Attractin Dppt-L Mahogany Homolog |
| Cellular Localisation | Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Secreted Isoform 3: Secreted |
| Alternative Antibody Names | Anti-Attractin antibody Anti-Dppt-L antibody Anti-Mahogany Homolog antibody Anti-ATRN antibody Anti-KIAA0548 antibody Anti-MGCA antibody |
Information sourced from Uniprot.org