| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AZU1 (27-251) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AZU1 |
| Gene ID: |
566 |
| Uniprot ID: |
CAP7_HUMAN |
| Immunogen Region: |
27-251 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 27-251 of human AZU1 (NP_001691.1). |
| Immunogen Sequence: |
IVGGRKARPRQFPFLASIQN QGRHFCGGALIHARFVMTAA SCFQSQNPGVSTVVLGAYDL RRRERQSRQTFSISSMSENG YDPQQNLNDLMLLQLDREAN LTSSVTILPLPLQNATVEAG TRCQVAGWGSQRSGGRLSRF PRFVNVTVTPEDQCRPNNVC TGVLTRRGGICNGDGGTPLV CEGLAHGVASFSLGPCGRGP DFFTRVALFRDWIDGVLNNP GPGPA |
| Post Translational Modifications | Cleavage of the N-terminal propeptide which is composed of 7 amino acids occurs in two steps. The initial cleavage of 5 amino acids is followed by the cleavage of a dipeptide to produce the mature form. |
| Function | This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria.this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G. |
| Protein Name | AzurocidinCationic Antimicrobial Protein Cap37Heparin-Binding ProteinHbpHhbp |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cytoplasmic Granule MembranePeripheral Membrane ProteinCytoplasmic SideLocalizes To Azurophil Granules Of Neutrophil GranulocytesAlso Called Primary GranulesThese Specialized Lysosomes Of The Neutrophil Formed Early During Promyelocyte Development Store Antibacterial Proteins And Peptides |
| Alternative Antibody Names | Anti-Azurocidin antibodyAnti-Cationic Antimicrobial Protein Cap37 antibodyAnti-Heparin-Binding Protein antibodyAnti-Hbp antibodyAnti-Hhbp antibodyAnti-AZU1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
