| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BPGM |
| Gene ID: | 669 |
| Uniprot ID: | PMGE_HUMAN |
| Immunogen Region: | 1-259 |
| Immunogen Sequence: | MSKYKLIMLRHGEGAWNKEN RFCSWVDQKLNSEGMEEARN CGKQLKALNFEFDLVFTSVL NRSIHTAWLILEELGQEWVP VESSWRLNERHYGALIGLNR EQMALNHGEEQVRLWRRSYN VTPPPIEESHPYYQEIYNDR RYKVCDVPLDQLPRSESLKD VLERLLPYWNERIAPEVLRG KTILISAHGNSSRALLKHLE GISDEDIINITLPTGVPILL ELDENLRAVGPHQFLGDQE |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-259 of human BPGM (NP_001715.1). |
| Tissue Specificity | Expressed in red blood cells. Expressed in non-erythroid cells of the placenta.present in the syncytiotrophoblast layer of the placental villi at the feto-maternal interface (at protein level). |
| Post Translational Modifications | Glycation of Lys-159 in diabetic patients inactivates the enzyme. |
| Function | Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase activity. |
| Protein Name | Bisphosphoglycerate MutaseBpgm2 -3-Bisphosphoglycerate Mutase - Erythrocyte2 -3-Bisphosphoglycerate Synthase2 -3-Diphosphoglycerate MutaseDpgmBpg-Dependent Pgam |
| Database Links | Reactome: R-HSA-70171 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Bisphosphoglycerate Mutase antibodyAnti-Bpgm antibodyAnti-2 -3-Bisphosphoglycerate Mutase - Erythrocyte antibodyAnti-2 -3-Bisphosphoglycerate Synthase antibodyAnti-2 -3-Diphosphoglycerate Mutase antibodyAnti-Dpgm antibodyAnti-Bpg-Dependent Pgam antibodyAnti-BPGM antibody |
Information sourced from Uniprot.org
