| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CABLES1 (1-368) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CABLES1 |
| Gene ID: |
91768 |
| Uniprot ID: |
CABL1_HUMAN |
| Immunogen Region: |
1-368 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-368 of human CABLES1 (NP_612384.1). |
| Immunogen Sequence: |
MLSKRGCHARIYADFPIRRL ISQRSSLETLEDIEENAPLR RCRTLSGSPRPKNFKKIHFI KNMRQHDTRNGRIVLISGRR SFCSIFSVLPYRDSTQVGDL KLDGGRQSTGAVSLKEIIGL EGVELGADGKTVSYTQFLLP TNAFGARRNTIDSTSSFSQF RNLSHRSLSIGRASGTQGSL DTGSDLGDFMDYDPNLLDDP QWPCGKHKRVLIFPSYMTTV IDYVKPSDLKKDMNETFKE |
| Tissue Specificity | Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers. |
| Post Translational Modifications | Phosphorylated on Ser-313 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3. |
| Function | Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death. |
| Protein Name | Cdk5 And Abl1 Enzyme Substrate 1Interactor With Cdk3 1Ik3-1 |
| Database Links | Reactome: R-HSA-69202Reactome: R-HSA-69656Reactome: R-HSA-983231 |
| Cellular Localisation | NucleusCytoplasmLocated In The Cell Body And Proximal Region Of The Developing Axonal Shaft Of Immature NeuronsLocated In Axonal Growth ConeBut Not In The Distal Part Of The Axon Shaft Or In Dendritic Growth Cone Of Mature Neurons |
| Alternative Antibody Names | Anti-Cdk5 And Abl1 Enzyme Substrate 1 antibodyAnti-Interactor With Cdk3 1 antibodyAnti-Ik3-1 antibodyAnti-CABLES1 antibodyAnti-CABLES antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
