| Function | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. |
| Protein Name | Cullin-Associated Nedd8-Dissociated Protein 1Cullin-Associated And Neddylation-Dissociated Protein 1Tbp-Interacting Protein Of 120 Kda ATbp-Interacting Protein 120aP120 Cand1 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8951664Reactome: R-HSA-917937 |
| Cellular Localisation | CytoplasmNucleusPredominantly Cytoplasmic |
| Alternative Antibody Names | Anti-Cullin-Associated Nedd8-Dissociated Protein 1 antibodyAnti-Cullin-Associated And Neddylation-Dissociated Protein 1 antibodyAnti-Tbp-Interacting Protein Of 120 Kda A antibodyAnti-Tbp-Interacting Protein 120a antibodyAnti-P120 Cand1 antibodyAnti-CAND1 antibodyAnti-KIAA0829 antibodyAnti-TIP120 antibodyAnti-TIP120A antibody |
Information sourced from Uniprot.org
