| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:5000-1:30000 IHC-P:1:500-1:2000 IF/ICC:1:200-1:800 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | IGF2R |
| Gene ID: | 3482 |
| Uniprot ID: | MPRI_HUMAN |
| Immunogen Region: | 2140-2300 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 2140-2300 of human Cation-independent M6PR (IGF2R) (NP_000867.3). |
| Immunogen Sequence: | TNPINGKSFSLGDIYFKLFR ASGDMRTNGDNYLYEIQLSS ITSSRNPACSGANICQVKPN DQHFSRKVGTSDKTKYYLQD GDLDVVFASSSKCGKDKTKS VSSTIFFHCDPLVEDGIPEF SHETADCQYLFSWYTSAVCP LGVGFDSENPGDDGQMHKGL S |
| Post Translational Modifications | Palmitoylated. Undergoes cysteine S-palmitoylation which promotes interaction with the retromer cargo-selective complex which mediates its retrograde trafficking to the Golgi apparatus. |
| Function | Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4. |
| Protein Name | Cation-Independent Mannose-6-Phosphate Receptor Ci Man-6-P Receptor Ci-Mpr M6pr 300 Kda Mannose 6-Phosphate Receptor Mpr 300 Insulin-Like Growth Factor 2 Receptor Insulin-Like Growth Factor Ii Receptor Igf-Ii Receptor M6p/Igf2 Receptor M6p/Igf2r Cd Antigen Cd222 |
| Database Links | Reactome: R-HSA-432722 Reactome: R-HSA-6798695 Reactome: R-HSA-6811440 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 |
| Cellular Localisation | Golgi Apparatus Membrane Single-Pass Type I Membrane Protein Endosome Membrane Mainly Localized In The Golgi At Steady State And Not Detectable In Lysosome Colocalized With Dpp4 In Internalized Cytoplasmic Vesicles Adjacent To The Cell Surface |
| Alternative Antibody Names | Anti-Cation-Independent Mannose-6-Phosphate Receptor antibody Anti-Ci Man-6-P Receptor antibody Anti-Ci-Mpr antibody Anti-M6pr antibody Anti-300 Kda Mannose 6-Phosphate Receptor antibody Anti-Mpr 300 antibody Anti-Insulin-Like Growth Factor 2 Receptor antibody Anti-Insulin-Like Growth Factor Ii Receptor antibody Anti-Igf-Ii Receptor antibody Anti-M6p/Igf2 Receptor antibody Anti-M6p/Igf2r antibody Anti-Cd Antigen Cd222 antibody Anti-IGF2R antibody Anti-MPRI antibody |
Information sourced from Uniprot.org