Anti-CD164 antibody

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Anti-CD164 antibody

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Product name Anti-CD164 antibody
Short Description Rabbit polyclonal against CD164
Description Rabbit polyclonal to CD164.
Applications ELISA, IHC
Dilution range IHC 1:100-1:300
ELISA 1:20000
Specificity CD164 Polyclonal Antibody detects endogenous levels of CD164 protein.
Protein Name Sialomucin core protein 24
Multi-glycosylated core protein 24
CD antigen CD164
Immunogen Synthesized peptide derived from human CD164
Immunogen Region 110-190 aa, C-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 8763
Gene Symbol CD164
Molecular Weight 20.011 kDa
Database Links HGNC:1632
Alternative Names Sialomucin core protein 24
Multi-glycosylated core protein 24
CD antigen CD164
Function Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes .
Post-translational Modifications Highly N- and O-glycosylated; contains sialic acid. The motif Ser-Gly may serve as the site of attachment of a glycosaminoglycan side chain.
Cellular Localization Lysosome membrane Endosome membrane Cell membrane Isoform 2: Secreted
Tissue Specificity Isoform 1 and isoform 3 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow
Swiss-Prot Key Q04900_HUMAN
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Nyegaard M, Rendtorff ND, Nielsen MS, et al.. A Novel Locus Harbouring a Functional CD164 Nonsense Mutation Identified in a Large Danish Family with Nonsyndromic Hearing Impairment. PlOS Genetics. 2015.  doi:10.1371/journal.pgen.1005386

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