Anti-CD222 antibody [MEM-238] (STJ16100179)

SKU:
STJ16100179-01

£445.50
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Host: Mouse
Applications: FC/IP/WB
Reactivity: Non-Human Primates/Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CD222 is suitable for use in Flow Cytometry, Immunoprecipitation and Western Blot research applications.
Clonality: Monoclonal
Clone ID: MEM-238
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Concentration: 1 mg/mL
Storage Instruction: Store at 2-8°C upon receipt.
Immunogen: Recombinant Vaccinia virus encoding CD222.
Background CD222 (CIMPR, cation-independent mannose 6-phosphate receptor; IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor) , plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria.

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance