• Immunohistochemical analysis of paraffin-embedded Human kidney. 1, Antibody was diluted at 1:100 (4°C overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).
  • Immunohistochemical analysis of paraffin-embedded Human kidney. 1, Antibody was diluted at 1:100 (4°C overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).
  • Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded Human kidney. 1, Antibody was diluted at 1:100 (4°C overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).
  • Western blot analysis of 293T 3T3 lysis using DPP4 antibody. Antibody was diluted at 1:500. Secondary antibody was diluted at 1:20000

Anti-DPP4 antibody (350-400 aa) (STJ97660)

SKU:
STJ97660

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Dipeptidyl peptidase 4 (350-400 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DPP4
Gene ID: 1803
Uniprot ID: DPP4_HUMAN
Immunogen Region: 350-400 aa
Specificity: CD26 Polyclonal Antibody detects endogenous levels of CD26 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human DPP4 at the amino acid range 350-400
Post Translational Modifications The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing. N- and O-Glycosylated. Phosphorylated. Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells. Mannose 6-phosphorylation is induced during T-cell activation.
Function Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. (Microbial infection) Acts as a receptor for human coronavirus MERS-CoV-2.
Protein Name Dipeptidyl Peptidase 4
Adabp
Adenosine Deaminase Complexing Protein 2
Adcp-2
Dipeptidyl Peptidase Iv
Dpp Iv
T-Cell Activation Antigen Cd26
Tp103
Cd Antigen Cd26 Cleaved Into - Dipeptidyl Peptidase 4 Membrane Form
Dipeptidyl Peptidase Iv Membrane Form - Dipeptidyl Peptidase 4 Soluble Form
Dipeptidyl Peptidase Iv Soluble Form
Database Links Reactome: R-HSA-381771
Reactome: R-HSA-400511
Cellular Localisation Dipeptidyl Peptidase 4 Soluble Form: Secreted
Detected In The Serum And The Seminal Fluid
Cell Membrane
Single-Pass Type Ii Membrane Protein
Apical Cell Membrane
Cell Projection
Invadopodium Membrane
Lamellipodium Membrane
Cell Junction
Membrane Raft
Translocated To The Apical Membrane Through The Concerted Action Of N- And O-Glycans And Its Association With Lipid Microdomains Containing Cholesterol And Sphingolipids
Redistributed To Membrane Rafts In T-Cell In An Interleukin-12-Dependent Activation
Its Interaction With Cav1 Is Necessary For Its Translocation To Membrane Rafts
Colocalized With Ptprc In Membrane Rafts
Colocalized With Fap In Invadopodia And Lamellipodia Of Migratory Activated Endothelial Cells In Collagenous Matrix
Colocalized With Fap On Endothelial Cells Of Capillary-Like Microvessels But Not Large Vessels Within Invasive Breast Ductal Carcinoma
Colocalized With Ada At The Cell Junction In Lymphocyte-Epithelial Cell Adhesion
Colocalized With Igf2r In Internalized Cytoplasmic Vesicles Adjacent To The Cell Surface
Alternative Antibody Names Anti-Dipeptidyl Peptidase 4 antibody
Anti-Adabp antibody
Anti-Adenosine Deaminase Complexing Protein 2 antibody
Anti-Adcp-2 antibody
Anti-Dipeptidyl Peptidase Iv antibody
Anti-Dpp Iv antibody
Anti-T-Cell Activation Antigen Cd26 antibody
Anti-Tp103 antibody
Anti-Cd Antigen Cd26 Cleaved Into - Dipeptidyl Peptidase 4 Membrane Form antibody
Anti-Dipeptidyl Peptidase Iv Membrane Form - Dipeptidyl Peptidase 4 Soluble Form antibody
Anti-Dipeptidyl Peptidase Iv Soluble Form antibody
Anti-DPP4 antibody
Anti-ADCP2 antibody
Anti-CD26 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance