Anti-CD48 antibody [HM48-1] {AF488} (STJA0004102)

SKU:
STJA0004102

Current Stock:
Host: Armenian Hamster
Applications: FC
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Armenian Hamster monoclonal antibody anti-Cd48 antigen
Clonality: Monoclonal
Clone ID: HM48-1
Conjugation: AF488
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 1% BSA
Concentration: 0.5 mg/mL
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: Cd48
Gene ID: 12506
Uniprot ID: CD48_MOUSE
Function Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells.
Protein Name Cd48 Antigen
Bcm1 Surface Antigen
Blast-1
Hm48-1
Mrc Ox-45 Surface Antigen
Slam Family Member 2
Slamf2
Signaling Lymphocytic Activation Molecule 2
Sgp-60
Cd Antigen Cd48
Database Links Reactome: R-MMU-202733
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Secreted
Alternative Antibody Names Anti-Cd48 Antigen antibody
Anti-Bcm1 Surface Antigen antibody
Anti-Blast-1 antibody
Anti-Hm48-1 antibody
Anti-Mrc Ox-45 Surface Antigen antibody
Anti-Slam Family Member 2 antibody
Anti-Slamf2 antibody
Anti-Signaling Lymphocytic Activation Molecule 2 antibody
Anti-Sgp-60 antibody
Anti-Cd Antigen Cd48 antibody
Anti-Cd48 antibody
Anti-Bcm-1 antibody

Information sourced from Uniprot.org

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