| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Ceramide synthase 2 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CERS2 |
| Gene ID: | 29956 |
| Uniprot ID: | CERS2_HUMAN |
| Specificity: | This antibody detects endogenous levels of LASS2 at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human LASS2 |
| Post Translational Modifications | Acetylated. Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation. Phosphorylated at the C-terminus by CK2, leading to increase the ceramide synthase activity. |
| Function | Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain. Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions. |
| Protein Name | Ceramide Synthase 2 Cers2 Lag1 Longevity Assurance Homolog 2 Sp260 Sphingosine N-Acyltransferase Cers2 Tumor Metastasis-Suppressor Gene 1 Protein Very-Long-Chain Ceramide Synthase Cers2 |
| Database Links | Reactome: R-HSA-1660661 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Ceramide Synthase 2 antibody Anti-Cers2 antibody Anti-Lag1 Longevity Assurance Homolog 2 antibody Anti-Sp260 antibody Anti-Sphingosine N-Acyltransferase Cers2 antibody Anti-Tumor Metastasis-Suppressor Gene 1 Protein antibody Anti-Very-Long-Chain Ceramide Synthase Cers2 antibody Anti-CERS2 antibody Anti-LASS2 antibody Anti-TMSG1 antibody |
Information sourced from Uniprot.org