| Function | Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. |
| Protein Name | Glutathione-Specific Gamma-Glutamylcyclotransferase 1Gamma-Gcg 1Blocks Notch ProteinBotchCation Transport Regulator-Like Protein 1 |
| Database Links | Reactome: R-HSA-174403Reactome: R-HSA-9648895 |
| Cellular Localisation | CytoplasmCytosolGolgi ApparatusTrans-Golgi Network |
| Alternative Antibody Names | Anti-Glutathione-Specific Gamma-Glutamylcyclotransferase 1 antibodyAnti-Gamma-Gcg 1 antibodyAnti-Blocks Notch Protein antibodyAnti-Botch antibodyAnti-Cation Transport Regulator-Like Protein 1 antibodyAnti-CHAC1 antibodyAnti-BOTCH antibody |
Information sourced from Uniprot.org
