| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-CCR4-NOT transcription complex subunit 3 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CNOT3 |
| Gene ID: | 4849 |
| Uniprot ID: | CNOT3_HUMAN |
| Specificity: | This antibody detects endogenous levels of CNOT3 at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human CNOT3 |
| Function | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation.may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation.the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. |
| Protein Name | Ccr4-Not Transcription Complex Subunit 3 Ccr4-Associated Factor 3 Leukocyte Receptor Cluster Member 2 |
| Database Links | Reactome: R-HSA-429947 Reactome: R-HSA-6804115 Reactome: R-HSA-9820841 |
| Cellular Localisation | Cytoplasm Nucleus P-Body Nanos2 Promotes Its Localization To P-Body |
| Alternative Antibody Names | Anti-Ccr4-Not Transcription Complex Subunit 3 antibody Anti-Ccr4-Associated Factor 3 antibody Anti-Leukocyte Receptor Cluster Member 2 antibody Anti-CNOT3 antibody Anti-KIAA0691 antibody Anti-LENG2 antibody Anti-NOT3 antibody |
Information sourced from Uniprot.org