| Function | Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
| Protein Name | Exportin-2Exp2Cellular Apoptosis Susceptibility ProteinChromosome Segregation 1-Like ProteinImportin-Alpha Re-Exporter |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusShuttles Between The Nucleus And The Cytoplasm |
| Alternative Antibody Names | Anti-Exportin-2 antibodyAnti-Exp2 antibodyAnti-Cellular Apoptosis Susceptibility Protein antibodyAnti-Chromosome Segregation 1-Like Protein antibodyAnti-Importin-Alpha Re-Exporter antibodyAnti-CSE1L antibodyAnti-CAS antibodyAnti-XPO2 antibody |
Information sourced from Uniprot.org
