Anti-CYP2S1 antibody (181-230 aa) (STJ92588)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Cytochrome P450 2S1 at the amino acid range 181-230
General Information
| Short Description | Rabbit polyclonal anti-Cytochrome P450 2S1 (181-230 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CYP2S1 |
| Gene ID | 29785 |
| Uniprot ID | CP2S1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Cytochrome P450 2S1 at the amino acid range 181-230 |
| Immunogen Region | 181-230 aa |
| Specificity | CYP2S1 Polyclonal Antibody detects endogenous levels of CYP2S1 protein. |
Additional Info
| Function | A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids. In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs). Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage. |
| Protein Name | Cytochrome P450 2s1Cypiis1Hydroperoxy Icosatetraenoate DehydrataseThromboxane-A Synthase |
| Database Links | Reactome: R-HSA-211958Reactome: R-HSA-211981Reactome: R-HSA-211999 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 2s1 antibodyAnti-Cypiis1 antibodyAnti-Hydroperoxy Icosatetraenoate Dehydratase antibodyAnti-Thromboxane-A Synthase antibodyAnti-CYP2S1 antibodyAnti-UNQ891 antibodyAnti-PRO1906 antibody |
Information sourced from Uniprot.org