| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DIO3 |
| Gene ID: | 1735 |
| Uniprot ID: | IOD3_HUMAN |
| Immunogen Region: | 70-170 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 70-170 of human DIO3 (NP_001353.4). |
| Immunogen Sequence: | HFLGRRRRGQPEPEVELNSE GEEVPPDDPPICVSDDNRLC TLASLKAVWHGQKLDFFKQA HEGGPAPNSEVVLPDGFQSQ HILDYAQGNRPLVLNFGSCT U |
| Tissue Specificity | Expressed in placenta and several fetal tissues. |
| Function | Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. Catalyzes the deiodination of L-thyroxine (T4) to 3,3',5'-triiodothyronine (rT3), 3,5,3'-triiodothyronine (T3) to 3,3'-diiodothyronine (3,3'-T2), 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine (3-T1), rT3 to 3',5'-diiodothyronine (3',5'-T2) and 3,3'-T2 to 3'-monoiodothyronine (3'-T1) via inner-ring deiodination (IRD). Catalyzes the deiodination of 3-T1 to L-thyronine (T0) via outer-ring deiodination (ORD). Catalyzes the tyrosyl ring deiodinations of 3,3',5,5'-tetraiodothyronamine, 3,3',5'-triiodothyronamine, 3,5,3'-triiodothyronamine, 3,5-diiodothyronamine, 3,3'-diiodothyronamine and 3-iodothyronamine. |
| Protein Name | Thyroxine 5-Deiodinase5diiiDioiiiType 3 DiType Iii Iodothyronine Deiodinase |
| Database Links | Reactome: R-HSA-350864 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinEndosome Membrane |
| Alternative Antibody Names | Anti-Thyroxine 5-Deiodinase antibodyAnti-5diii antibodyAnti-Dioiii antibodyAnti-Type 3 Di antibodyAnti-Type Iii Iodothyronine Deiodinase antibodyAnti-DIO3 antibodyAnti-ITDI3 antibodyAnti-TXDI3 antibody |
Information sourced from Uniprot.org
