• Western blot analysis of lysate from HUVEC cells, using DIO3 antibody.
  • Western blot analysis of various cells using DIO3 Polyclonal Antibody

Anti-DIO3 antibody (17-66 aa) (STJ92717)

SKU:
STJ92717

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Thyroxine 5-deiodinase (17-66 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DIO3
Gene ID: 1735
Uniprot ID: IOD3_HUMAN
Immunogen Region: 17-66 aa
Specificity: DIO3 Polyclonal Antibody detects endogenous levels of DIO3 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human DIO3 at the amino acid range 17-66
Function Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
Protein Name Thyroxine 5-Deiodinase
5diii
Dioiii
Type 3 Di
Type Iii Iodothyronine Deiodinase
Database Links Reactome: R-HSA-350864
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Endosome Membrane
Alternative Antibody Names Anti-Thyroxine 5-Deiodinase antibody
Anti-5diii antibody
Anti-Dioiii antibody
Anti-Type 3 Di antibody
Anti-Type Iii Iodothyronine Deiodinase antibody
Anti-DIO3 antibody
Anti-ITDI3 antibody
Anti-TXDI3 antibody

Information sourced from Uniprot.org

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