Immunofluorescence analysis of L929 cells using DLAT antibody (STJ116741) at dilution of 1:100. Blue: DAPI for nuclear staining.

Anti-DLAT antibody (87-270) (STJ116741)

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STJ116741
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Applications:WB/IHC-P/IF/ICC/ELISA
Host:Rabbit
Reactivity:Human/Mouse/Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Concentration:Lot specific
Purification:Affinity purification
Dilution Range:WB:1:500-1:2000
IHC-P:1:50-1:100
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation:PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:DLAT
Gene ID:1737
Uniprot ID:ODP2_HUMAN
Immunogen Region:87-270
Immunogen Sequence:SLPPHQKVPLPSLSPTMQAG TIARWEKKEGDKINEGDLIA EVETDKATVGFESLEECYMA KILVAEGTRDVPIGAIICIT VGKPEDIEAFKNYTLDSSAA PTPQAAPAPTPAATASPPTP SAQAPGSSYPPHMQVLLPAL SPTMTMGTVQRWEKKVGEKL SEGDLLAEIETDKATIGFEV QEEG
Specificity:Recombinant fusion protein containing a sequence corresponding to amino acids 87-270 of human DLAT (NP_001922.2).
Post Translational Modifications Delipoylated at Lys-132 and Lys-259 by SIRT4, delipoylation decreases the PHD complex activity.
Function As part of the pyruvate dehydrogenase complex, catalyzes the transfers of an acetyl group to a lipoic acid moiety (Probable). The pyruvate dehydrogenase complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle (Probable).
Protein Name Dihydrolipoyllysine-Residue Acetyltransferase Component Of Pyruvate Dehydrogenase Complex - Mitochondrial
70 Kda Mitochondrial Autoantigen Of Primary Biliary Cirrhosis
Pbc
Dihydrolipoamide Acetyltransferase Component Of Pyruvate Dehydrogenase Complex
M2 Antigen Complex 70 Kda Subunit
Pyruvate Dehydrogenase Complex Component E2
Pdc-E2
Pdce2
Database Links Reactome: R-HSA-204174
Reactome: R-HSA-5362517
Reactome: R-HSA-9857492
Reactome: R-HSA-9861559
Cellular Localisation Mitochondrion Matrix
Alternative Antibody Names Anti-Dihydrolipoyllysine-Residue Acetyltransferase Component Of Pyruvate Dehydrogenase Complex - Mitochondrial antibody
Anti-70 Kda Mitochondrial Autoantigen Of Primary Biliary Cirrhosis antibody
Anti-Pbc antibody
Anti-Dihydrolipoamide Acetyltransferase Component Of Pyruvate Dehydrogenase Complex antibody
Anti-M2 Antigen Complex 70 Kda Subunit antibody
Anti-Pyruvate Dehydrogenase Complex Component E2 antibody
Anti-Pdc-E2 antibody
Anti-Pdce2 antibody
Anti-DLAT antibody
Anti-DLTA antibody

Information sourced from Uniprot.org

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