| Short Description : | Rabbit polyclonal DLGAP5 (547-846) antibody for use in WB, IF, ICC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DLGAP5 |
| Gene ID: | 9787 |
| Uniprot ID: | DLGP5_HUMAN |
| Immunogen Region: | 547-846 |
| Immunogen Sequence: | KNVFRKKVVSGIASKPKQDD AGRIAARNRLAAIKNAMRER IRQEECAETAVSVIPKEVDK IVFDAGFFRVESPVKLFSGL SVSSEGPSQRLGTPKSVNKA VSQSRNEMGIPQQTTSPENA GPQNTKSEHVKKTLFLSIPE SRSSIEDAQCPGLPDLIEEN HVVNKTDLKVDCLSSERMSL PLLAGGVADDINTNKKEGIS DVVEGMELNSSITSQDVLMS SPEKNTASQNSILEEGETK |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 547-846 of human DLGAP5 (NP_055565.3). |
| Tissue Specificity | Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta. |
| Post Translational Modifications | Ubiquitinated, leading to its degradation. Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells. |
| Function | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. |
| Protein Name | Disks Large-Associated Protein 5Dap-5Discs Large Homolog 7Disks Large-Associated Protein Dlg7Hepatoma Up-Regulated ProteinHurp |
| Database Links | Reactome: R-HSA-9013508 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonSpindleLocalizes To The Spindle In Mitotic CellsColocalizes With Cdh1 At Sites Of Cell-Cell Contact In Intestinal Epithelial Cells |
| Alternative Antibody Names | Anti-Disks Large-Associated Protein 5 antibodyAnti-Dap-5 antibodyAnti-Discs Large Homolog 7 antibodyAnti-Disks Large-Associated Protein Dlg7 antibodyAnti-Hepatoma Up-Regulated Protein antibodyAnti-Hurp antibodyAnti-DLGAP5 antibodyAnti-DLG7 antibodyAnti-KIAA0008 antibody |
Information sourced from Uniprot.org
